Verification Bias—impact and Methods for Correction When Assessing Accuracy of Diagnostic Tests
نویسنده
چکیده
• Sometimes it is not feasible to obtain disease status verification for all study subjects. Analysis of only those with disease ascertainment can result in biased estimates of the accuracy (sensitivity, specificity, ROC curve) of a diagnostic test, screening test, or biomarker if the estimation method does not properly account for the missing disease ascertainment. This paper discusses the impact of this bias, verification bias, when estimating the accuracy of dichotomous and continuous diagnostic tests. In addition, methods to correct for verification bias are described. Areas that require additional attention are also highlighted.
منابع مشابه
Assessing accuracy of a continuous screening test in the presence of verification bias
In studies to assess the accuracy of a screening test, often definitive disease assessment is too invasive or expensive to be ascertained on all the study subjects. Although it may be more ethical or cost effective to ascertain the true disease status with a higher rate in study subjects where the screening test or additional information is suggestive of disease, estimates of accuracy can be bi...
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تاریخ انتشار 2014